If you're a guy who really likes a sunroof, like me, you're always going to miss not having one, and ultimately going to find a reason to trade up to another ride with a sunroof.
When I get into a car without one, I'm never really comfortable. Perhaps I'm somewhat claustrophobic, but without the roof open, or at least the upholstered panel pulled back so I can see the sky, the car just seems to close in on me.
Most of the summer, I can drive with the roof open and the a/c on. And during the winter milder temps, open the roof and put the heat on. Spring & Fall, open except during squalls.