yes it is possible. as stated above you will need to run a power wire from the battery. you can get audio signal from the factory amp (i don't know if it's high or low level) and you might be able to get a turn on from it as well as long as it's a 12 volt turn on and not digital. if it's digital then you will need to run it from the ignition.
2013 F150 4x4 SCrew XLT 5.0L
Midwest Crew #22
Official FocusFest Event Planner