I keep my Kel-Tec P11 in a soft case in the center console, barrel down. I keep the soft case open enough where I can pull it out easy enough. The soft case helps keep it from banging inside the console and keeps it nice and centered.
If I do need to lock it up, since our glove boxes do not lock I have one of these:
Fits perfect in the slot meant for the car user manual. I have the cable looped through the back of the glove box. I generally only use it if I am valet parking, or at the car wash or having the car serviced. Otherwise it stays in the console.