I am getting about 37MPG so far with about 350 miles on the clock, cruise set between 55-65, 80 mile commute with 85% highway driving. I am very happy, compared with my Fusion Sport AWD that got around 24MPG.
I filled it up when it was at 0 miles to empty (yes, I was far from the next gas station, I won't do it again, promise) and it took 11.5 gallons of gas. I am thinking it must have about 1 galllon reserve when showing empty (which is good).
I also dislike the EcoMode, it's cool when you first buy the car but useless to me at this point. It's always maxed out, flowers all green and I am always an Eco Champion. Like Jazzdog said above, I would rather have an instant MPG in a bar graph like the new Edge or F-150.